报告题目：Evolution and function of calcitropic hormones

报告人：Prof. Adelino Canario葡萄牙阿尔加夫大学CCMAR海洋研究中心主任（欧盟重点实验室）

Abstract:Calcium is a key ion for cell responsiveness and as part of the cement that binds animal skeletons. Extracellular levels of free calcium need to be tightly regulated by the endocrine system. Although, not a settled issue, in tetrapods it is generally considered that calcitonin and parathyroid hormone (PTH) act as antagonists to bring about calcium constancy. In teleost fish, however, stanniocalcin 1 (STC1) and PTH-related protein (PTHrP) appear to have such an action.  PTH family members are present in jawless and cartilaginous fishes. Teleost fishes, with an extra round of genome duplication, have 5 PTH family genes, including duplicated PTH and PTHrP genes, and 3 PTH receptor genes. In all studied tetrapods, 3 PTH family genes are present, except in eutherian mammals, which only have PTH and PTHrP. The number of PTH receptors in tetrapods varies between 2 and 3. STC genes have been identified in urochordates, although STC immunoreactivity has been detected in protostomes. In vertebrates, 2 STC genes are generally found, except in teleosts which have 4. STC1 is produced in the corpuscles of Stannius, a unique teleost fish gland.  In higher vertebrates, STC1 and STC2 are expressed in many tissues and are considered a paracrine/autocrine/intracrine factor. Although some of the described actions of STCs are linked with phosphate reabsorption in the renal tubules, multiple actions have been identified, including an anti-apoptotic effect. Altogether, available information suggests that the calciotropic actions of STC1 and PTHrP may be a specialization of two proteins with a wide spectrum of functions.

时间：2012年4月6日上午10：00—11：00

地点：水产与生命学院A101学术报告厅

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